The two numbers
Return to Player is the percentage of total wagers a game returns to players over a very large sample. House edge is the remainder. A 96% RTP slot has a 4% house edge; a blackjack game with a 0.5% edge has a 99.5% RTP. They are the same fact stated from opposite ends.
The crucial detail is that both apply to total amount wagered, not to your deposit. Wagering 100 twenty times means 2,000 in turnover, and a 4% edge on that is an expected 80 cost — far more than 4% of what you brought.